Folding the proteome
نویسندگان
چکیده
منابع مشابه
Proteome folding and aggregation.
The description of protein folding at the proteome level requires further principles in addition to those that govern this phenomenon for individual molecules. An important aspect of the increased complexity of the folding process in the cellular environment is that proteins tend to be metastable against aggregation, as they are often expressed at levels at which they are poorly soluble. The ma...
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How heterogeneous are proteome folding timescales and what physical principles, if any, dictate its limits? We answer this by predicting copy number weighted folding speed distribution - using the native topology - for E.coli and Yeast proteome. E.coli and Yeast proteomes yield very similar distributions with average folding times of 100 milliseconds and 170 milliseconds, respectively. The topo...
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With the advent of proteomics, there is an increasing need of tools for predicting the properties of large numbers of proteins by using the information provided by their amino acid sequences, even in the absence of the knowledge of their structures. One of the most important types of predictions concerns whether proteins will fold or aggregate. Here, we study the competition between these two p...
متن کاملIn vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome.
A question of fundamental importance concerning protein folding in vivo is whether the kinetics of translation or the thermodynamics of the ribosome nascent chain (RNC) complex is the major determinant of cotranslational folding behavior. This is because translation rates can reduce the probability of cotranslational folding below that associated with arrested ribosomes, whose behavior is deter...
متن کاملThe Plant Proteome Folding Project: Structure and Positive Selection in Plant Protein Families
Despite its importance, relatively little is known about the relationship between the structure, function, and evolution of proteins, particularly in land plant species. We have developed a database with predicted protein domains for five plant proteomes (http://pfp.bio.nyu.edu) and used both protein structural fold recognition and de novo Rosetta-based protein structure prediction to predict p...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2013
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2013.05.001